Technical Meeting:
Prevention and Control in People living with HIV, Immunobridging landscape, DNA Methylation in cervical cancer screening
Hybrid meeting, Antwerp, Belgium – June 2022
Meeting Objectives
- HPV prevention and control in People Living With HIV
- Discuss and review the HPV vaccine schedule for People Living With HIV
- Discuss HPV screening of People Living With HIV
- Discuss and review the management of women with HIV who are HPV positives
- Benefits and Challenges of Immunobridging trials
- Discuss availability and use of different HPV immunoassays
- Discuss challenges and prospects of immunobridging trials for evaluating current and future HPV vaccines
- DNA Methylation as a triage tool for cervical cancer screening
- Provide an overview of the use of DNA methylation in the oncology field
- Provide an overview of different DNA methylation assays and methods
- Discuss the use of DNA methylation as a novel biomarker for triage of human papillomavirus (HPV) positive women at screening
DAY 1 – Thursday, 2 June 2022
SESSION 1 : WELCOME AND INTRODUCTION
SESSION 2: HPV PREVENTION AND CONTROL IN PEOPLE LIVING WITH HIVChairs: Maribel Almonte & Silvia de Sanjose
- Global HIV Epidemiology and the intersection with HPV and cervical cancer burden
Gary Clifford (pdf, video) - Performance and effectiveness of screeningtriage strategies for cervical precancer among women living with HIV
Helen Kelly (pdf, video) - Questions and Discussion (video)
- Improving HPV & precancer treatment among WLWH in LMICs: The Low Hanging Fruit
Chemtai Mungo (pdf, video) - Questions and Discussion (video)
- HPV vaccination in people living with HIV
Sinead Delany-Moretlwe (pdf, video) - Questions and Discussion (video)
- Keynote lecture: Prevention of anal cancer in males and females living with HIV
Joel Palefsky
SESSION 3: BENEFITS AND CHALLENGES OF IMMUNOBRIDGING
Chairs: Partha Basu & Deborah Watson-Jones
- Immunogenicity of HPV prophylactic vaccines: Serology assays and their use in HPV vaccine evaluation and development. Importance of international units for reporting immune response
Carina Eklund (pdf, video)
- Neutralizing and cross-neutralizing antibody levels to human papillomavirus following vaccination
Filipe Colaço Mariz (pdf, video) - Questions and Discussion (video)
- Current status of using urine samples to monitor HPV vaccination status
Alex Vorsters & Laura Téblick (pdf, video)
- Monitoring of HPV vaccination programs
Iacopo Baussano - Questions and Discussion (video)
- Update on April 2022 SAGE advice on HPV schedule optimization and the permissive single dose recommendation in younger women
Paul Bloem (pdf, video)
- One dose modelling study in India
Iacopo Baussano - Questions and Discussion (video)
SESSION 3A: PANEL DISCUSSION
One dose
Chairs: Margaret Stanley & Peter Dul
- Single-dose HPV vaccination efficacy among adolescent girls and young women in Kenya (the KEN SHE Study): study protocol for a randomized controlled trial
Nelly Mugo (Pdf, video) - The DoRIS trial results to M36-immunogenicity of 1 dose of gardasil9®and cervarix® in Tanzanian girls aged 9-14Y and M24 immunobridging results
Deborah Watson-Jones (pdf, video) - Costa Rica HPV Vaccine Trials
Aimee Kreimer (pdf, video) - Multicentric cohort study to compare efficacy of a single dose of 4-HPV vaccine compared to two &three doses in 10-18 yr old females in India
Partha Basu (pdf, video) - Hope Study: Population impact of a single HPV vaccine dose on HPV 16/18 prevalence among South African adolescent girls
Sinead Delany-Moretlwe (pdf, video) - Panel discussion – Speakers and participants (video)
Nelly Mugo, Deborah Watson-Jones, Aimee Kreimer, Sinead Delany-Moretlwe, Paul Bloem, Gary Clifford, Partha Basu
Topics:
- One dose
- One dose use in women living with HIV
- Implementation of one dose in LMICs
DAY 2 – Friday, June 6, 2025
SESSION 4: DNA METHYLATION AS A TRIAGE TOOL FOR CERVICAL CANCER SCREENING
Chairs: Mario Poljak & Kate Cuschieri
- Welcome
Alex Vorsters - Methylation in predicting progression of untreated high-grade cervical intraepithelial neoplasia
Karolina Louvanto (pdf, video) - Overview of different DNA methylation assays used in HPV screening
Mariam El-Zein (pdf, video) - Methylation patterns of host cell DNA and the heterogeneous nature of cervical pre-cancer
Daniëlle Heideman (video) - Methylation of viral DNA and combined viral and host DNA methylation
Jack Cuzick - DNA methylation testing on clinician-collected cervical and self-collected vaginal samples for identification of cervical lesions in high-risk HPV positive women
Johannes Berkhof (pdf, video) - Human Papillomavirus DNA Methylation as a Biomarker for Cervical Precancer: Consistency across 12 Genotypes and Potential Impact on Management of HPV-Positive Women
Megan Clarke (pdf, video) - Questions and Discussions. (video)
- Could DNA methylation be used as a primary cervical screening method?
Belinda Nedjai (pdf, video) - Evaluation of cervical screening strategies using methylation markers in WLHIV
Chris Meijer (pdf, video) - The standing of self-collected urine samples for DNA methylation in cervical screening
Severien Van Keer (pdf, video) - Questions and Discussions (video)
SESSION 5: BREAKOUT SESSION
Chairs: Alex Vorsters & Marc Arbyn
- Breakout Group 1: HPV Prevention and Control in HIV Positives – challenges and lessons learnt
Chairs: Marc Steben & Sharon Hanley - Breakout Group 2: Benefits and Challenges of Immunobridging
Chairs: Eduardo Franco & Suzanne Garland - Breakout Group 3: DNA Methylation as a triage tool for HPV positives – challenges and lessons learnt
Chairs: Murat Gultekin & Johannes Berkhof
Plenary Feedback
SESSION 6: MEETING CONCLUSION AND CLOSING REMARKS
Chairs: Narendra Kumar Arora & Alex Vorsters