Technical Meeting:

HPV Vaccination of Adults: Impact, Opportunities and Challenges

 Antwerp, Belgium – November 2019

 

Meeting Objectives
  • Provide an overview of the current situation of the HPV vaccine for adults.
  • Discuss the immunogenicity, safety and efficacy data of existing HPV vaccine studies in adults.
  • Gain insight into the efficacy of the HPV vaccine at the mucosal level and systemic level.
  • Discuss ways and methods to conduct research on the potential benefits of vaccinating exposed adults.
  • Discuss the challenges and benefits of vaccination of adults including high risk groups.
  • Discuss cervical cancer elimination strategies.
  • Discuss the potential implications of vaccination of adults on vaccine supplies in Low and Middle-Income Countries (LMIC).

Background document 

DAY 1 – Thursday, November 14, 2019

OPENING AND OBJECTIVES

SESSION 1: SITUATIONAL ANALYSIS OF HPV VACCINATION OF ADULTS: IMUNOGENECITY AND SAFETY DATA
Chairs: Alex Vorsters & Pierre Van Damme

  • Efficacy and safety of prophylactic HPV vaccination in adults.
    Marc Arbyn

 

  • Immunogenicity and tolerability of HPV vaccine in women aged 15-55 years; study findings and way forward.
    Tino F. Schwarz (PDF) (Video) 

 

  • Questions & Discussion

SESSION 2: HPV IMMUNOLOGICAL DYNAMICS AT MUCOSAL AND SYSTEMIC LEVEL
Chairs: Mario Poljak & Marc Arbyn

      • Potential Benefits of HPV Vaccine in sexually active women: delivering the promise.
        John Schiller  (PDF) (Video) 

      • Immune cross talk of HPV Specific Antibody Response; Cross Reactivity, Neutralizing Activity, Mucosal Secretion and Infection Prevention.
        Fiona RM van der Klis  (PDF) (Video) 

       

      • Vaccine-induced HPV-specific antibodies in cervicovaginal secretions.
        Jade Pattyn (PDF) (Video) 

       

      • Immunising older cohorts : pros and cons 
        Margaret Stanley & Xavier Bosch (PDF) (Video) 

       

      • Questions & Discussion

       

      SESSION 3: COMPREHENSIVE ANALYSIS OF CHALLENGES AND POTENTIAL BENEFITS OF HPV VACCINATION OF ADULTS
      Chairs:  Eduardo Franco & Iacopo Bausanno

      • Pap smear collection: an increased risk of HPV infection? An objective study in rhesus macaques’ model. 
        John Schiller (PDF) (Video) 

       

      • HPV vaccine post treatment: a pathway to prevent disease relapse.
        Marta del Pino (PDF) 

       

      • HPV vaccination in relation to conization: A Danish nationwide study. 
        Susanne Krüger Kjær (PDF) (Video) 

       

      • Questions & Discussion. 

       

      • Transmission Reduction and Prevention with HPV Vaccination (TRAP-HPV) study. 
        Aaron MacCosham and Eduardo Franco (PDF) (Video) 

       

      • Predicting cohort-specific cervical cancer incidence from population-based HPV prevalence surveys.                                          
        Iacopo Bausanno    

       

      • Overview of Health Economics Models for HPV Vaccination of Mid-Adults. 
        Harrell Chesson (PDF) (Video) 

       

      • Questions & Discussion. 

       

      • Breakout Session
        Chairs: Paolo Bonanni & Susanne Krüger Kjær

        – Pap smear; an increased risk for HPV infections? – How to deal with it?
        – Are vaccinated women less prone to transmit infections – What are the ways to investigate it?

         

      • Plenary feedback from different groups

      DAY 2 – Friday, November 15th 2019

      SESSION 4: HPV VACCINATION OF HIGH-RISK GROUPS
      Chairs: Mira Kojouharova & Sharon Hanley​

      • Directionality of HPV Infection transmission in heterosexual couples; a systematic review and meta-analysis. 
        Aaron MacCosham & Eduardo Franco (PDF) (Video) 

       

      • HPV Vaccination for sex workers: finding a balance between pros and cons. 
        Maarten Schim van der Loeff (PDF) (Video) 

       

      • Baseline HPV Prevalence in rectal swabs from men attending a sexual health clinic in Scotland: assessing the potential impact of a selective HPV Vaccination programme for men who have sex with men. 
        Ross Cameron (PDF) (Video) 

       

      • Questions & Discussion

      SESSION 5: LIMITATIONS AND ELIMINATION GOALS
      Chairs: Mark Kane & Luidmila Mosina

      • Towards cervical cancer elimination: the context of HPV Vaccination. 
        Paul Bloem (PDF)  (Video) 

       

      • Questions & Discussion

      BREAKOUT SESSIONS
      Chairs:  Paul Bloem & Emilie Karafillakis

      Outcome of the meeting, current challenges and strategies to deal with challenges: Where do we stand today? 

      • Plenary feedback from each group and discussion

      CONCLUSION OF THE MEETING
      Chairs: Pierre Van Damme & Xavier Bosch

      • Conclusion and Closing remarks (PDF)